Substances Authority for information on how to prevent and detect abuse or diversion of this product. Interactions with other CNS Depressants. Medscape – Detoxification, pain-specific dosing for Methadose, Dolophine opioids; Substantial interpatient variability, see prescribing information for guidance. Find patient medical information for Dolophine Oral on WebMD including its uses , side effects and safety, interactions, pictures, warnings and user ratings.

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In most samples, the milk concentrations prescribinb lower than maternal serum drug concentrations at steady state. Methadone treatment for acute or chronic pain management should only be initiated if the potential analgesic or palliative care benefits outweigh the risks.

Divide the total daily methadone dose into an appropriate daily regimen. Injectable methadone is not approved for the outpatient treatment of opioid dependence.

Intravenous methadone should only be used on a temporary basis for patients who cannot take oral medication, such as hospitalized inpatients. Initially, use a 2: Assess patients for risks of addiction, abuse, or misuse before drug initiation, and monitor patients who receive opioids routinely for development of these behaviors or conditions.

In opioid-tolerant patients, convert the current total daily dose of all opioids to an oral morphine equivalent dose, then multiply the morphine equivalent dose by the corresponding percentages in the dose conversion table provided in the FDA-approved labeling. Although true opiate agonist hypersensitivity is rare, patients who have demonstrated a prior hypersensitivity reaction should not receive methadone.

If concurrent use is necessary, use the lowest effective doses and minimum treatment durations possible and monitor patients closely for signs and symptoms of respiratory depression and sedation. Use with caution in patients with GI disease including GI obstruction, ulcerative colitis, or pre-existing constipation.

In ambulatory patients, a somewhat slower schedule dolopnine be required. If clinically indicated, patients may informaton enrolled directly into a maintenance program without first attempting detoxification since the purpose of the maintenance program is to provide a stable dose of methadone as a substitute for illicit opiate use.

Methadone therapy requires an experienced clinician skilled in the use of potent opioids for chronic pain or opioid addiction. Medical withdrawal of pregnant, opioid-dependent women from methadone is not recommended. Advise breast-feeding women taking methadone to monitor the infant for increased drowsiness and breathing difficulty. Methadone should be avoided in patients treated with monoamine oxidase inhibitor therapy MAOI therapydue to the potential risk for serotonin syndrome.


Methadone should be used cautiously in patients with cardiac arrhythmias, hypokalemia, hypomagnesemia, hypotension, hypovolemia, or orthostatic hypotension. The severity of the withdrawal syndrome produced will depend on the degree of physical dependence and on the administered dose of the opioid antagonist.

Individuals receiving palliative care or those in hospice settings are excluded peescribing the Beers Criteria; the balance of benefits and harms of medication management for these patients may differ from those of the general population of older adults. The Guidelines caution that opioids may cause constipation, nausea, vomiting, sedation, lethargy, weakness, confusion, dysphoria, physical and psychological dependency, hallucinations, and unintended respiratory depression, especially in individuals with compromised pulmonary function.

In addition, chronic opioid use may lead to symptoms of colophine, resulting from changes in the hypothalamic-pituitary-gonadal axis. Patients receiving methadone should be warned about the possibility of sedation occurring during methadone administration and to use caution when driving or operating machinery. Prolonged maternal use of opioids, such as methadone, during pregnancy may result in neonatal opioid withdrawal syndrome NOWS. Pregnant women may require dose adjustments during pregnancy pescribing provide effective dosing.

Patients who are maintained on methadone will react to life problems and stresses with the same anxiety symptoms as other individuals. Patients receiving opioid dependance maintenance therapy with methadone are often under-treated or denied pain treatment.

Brain tumor, CNS depression, coma, head trauma, increased intracranial pressure, intracranial mass. Due to the absence of data regarding methadone use in patients with renal impairment, caution is recommended. Morphine is well recognized to increase the tone of the biliary tract causing spasms especially in the sphincter of Oddi increasing biliary tract pressure. Abrupt informmation of methadone in the methadone-maintained patient should be discouraged due to the potential for opioid withdrawal symptoms including lacrimation, rhinorrhea, sneezing, yawning, excessive perspiration, piloerection goose bumpsfever, chills, flushing, restlessness, irritability, weakness, anxiety, depression, dilated pupils, tremors, tachycardia, abdominal cramps, body aches, involuntary twitching and kicking movements, anorexia, nausea, vomiting, diarrhea, intestinal spasms, and weight loss.


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Methadone should be reserved for patients in whom alternative treatment options e. Methadone should be used cautiously in patients with a seizure disorder. Intravenous, Subcutaneous, or Intramuscular dosage. Measure dosage using a calibrated measuring device. Special care should be taken to keep it out of the reach of patients for whom it was not prescribed, particularly pediatric patients, as accidental exposure may cause fatal overdose.

Dosage, interval, length of treatment, and taper schedule must be individualized based on patient’s previous opioid dose and symptoms of withdrawal.

Methadone Dolophine, Methadose – Treatment – Hepatitis C Online

Although opiate agonists are contraindicated for use in patients with diarrhea secondary to poisoning or infectious diarrhea, antimotility agents have been used successfully in these patients. In addition to slowing the rate of cardiac repolarization thus lengthening the QT interval, methadone may produce cholinergic side effects by stimulating medullary vagal nuclei causing bradycardia and induce the release of histamine causing peripheral vasodilation. Children born to mothers who received methadone during pregnancy demonstrate mild but persistent performance deficits on psychometric and behavioral tests and may have an increased risk of visual development anomalies.

The risk of addiction in any individual is unknown. Abrupt discontinuation of methadone therapy can result in withdrawal symptoms, which may not be seen for days after the last dose in patients on chronic therapy.

Methadone is not recommended for analgesia during labor and obstetric delivery due to its long duration of action and potential for respiratory depression in the newborn.

Patients previously prescribed methadone who have not taken opioids for 1 to 2 weeks should be considered opioid-naive for the purposes of methadone reinitiation. Nevertheless, methadone should be used with caution in patients with biliary tract disease, including acute pancreatitis, or in patients undergoing biliary tract surgery. False positive urine drug screens for methadone have been reported for several drugs including diphenhydramine, doxylamine, clomipramine, chlorpromazine, thioridazine, quetiapine, and verapamil.